Rejuran Healer & Polynucleotides in Abu Dhabi

Rejuran Healer in Abu Dhabi is the skin treatment that started a dermatology revolution in South Korea and has since become one of the most requested injectable skin quality treatments globally. Also known as salmon DNA therapy, PDRN, or polynucleotides, Rejuran works by delivering highly purified chains of nucleic acids \u2014 extracted from salmon milt \u2014 directly into the dermis, where they stimulate your skin’s own repair mechanisms at the cellular level. The result is genuine tissue regeneration: denser collagen, improved elastin, better hydration, and measurably better skin quality that develops progressively over a course of sessions.

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At House of Skincare on Yas Island, Rejuran and polynucleotide treatments are performed by Dr. Khadija Al Zaabi, DOH-licensed Consultant Dermatologist with over 21 years of clinical experience. This is not a delegated treatment. Dr. Al Zaabi selects the product formulation, sets the injection depth and pattern, and assesses your skin’s response at every session \u2014 because the clinical decisions made at each stage determine how well your skin responds.

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Why House of Skincare for Rejuran Healer?

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Dr. Al Zaabi works with the full Rejuran product range \u2014 Rejuran Healer, Rejuran S (for acne scarring), and Rejuran I (periorbital and under-eye) \u2014 selecting the formulation that matches your specific presentation rather than applying a one-size protocol. The injection technique matters as much as the product: depth, distribution, and concentration all affect whether the fibroblast response is optimal.

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House of Skincare holds a 4.9-star patient rating on Google. Every polynucleotide session is physician-led. For a treatment where technique is everything, clinical experience at the level Dr. Al Zaabi brings is not a luxury \u2014 it is what separates consistent results from inconsistent ones.

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What Is Rejuran Healer? The Salmon DNA Story

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Rejuran Healer is a PDRN-based injectable developed by a South Korean pharmaceutical company and validated in clinical trials for skin quality improvement, collagen stimulation, and wound healing. Its active ingredient \u2014 polydeoxyribonucleotide, or PDRN \u2014 is extracted from salmon sperm cells (salmon milt), then subjected to an enzymatic hydrolysis process that breaks the DNA into short-chain nucleotide fragments and removes all proteins, allergens, and biological material. What remains is a purified polymer of DNA building blocks that is biocompatible with human tissue.

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The reason salmon DNA works in human skin is straightforward: the nucleotide building blocks of DNA \u2014 adenine, thymine, cytosine, guanine \u2014 are identical across all vertebrate species. Human fibroblasts recognise these fragments not as foreign material but as cellular fuel. When injected into the dermis, PDRN activates purinergic A2A receptors on fibroblasts, triggering a cascade of cellular responses: increased collagen and elastin synthesis, reduced inflammation, improved microcirculation, and accelerated tissue repair. The skin is not being supplemented \u2014 it is being instructed to regenerate.

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Rejuran comes in several clinical formulations:

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Rejuran Healer: The original formulation. A 2mg/ml PDRN injectable for overall skin quality improvement \u2014 fine lines, texture, hydration, and skin density across the face, neck, and d\u00e9colletage.

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Rejuran S: A higher-viscosity formulation designed specifically for acne scar remodelling. The thicker consistency provides more structural support within the scar bed, promoting tissue regeneration in atrophic and rolling scar tissue.

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Rejuran I: A lower-viscosity formulation for the delicate periorbital and under-eye area, where the skin is thinner and the injection depth must be more precise. Used for crepey under-eye skin, fine periorbital lines, and mild dark circles caused by skin thinning.

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Dr. Al Zaabi selects the appropriate Rejuran formulation based on your skin concern and anatomy at your initial assessment.

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What Does Rejuran Treat?

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Fine lines and skin crepiness: Declining collagen density causes skin to lose structural firmness and develop fine lines. Rejuran’s fibroblast activation stimulates new collagen production, progressively thickening and firming the dermal layer. Most visible in crepey skin around the eyes, mouth, and neck.

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Skin thinning and laxity: Thin, fragile skin that has lost density \u2014 particularly in the cheeks, temples, and neck \u2014 responds strongly because Rejuran increases both collagen and elastin production simultaneously, addressing the structural deficit rather than masking it.

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Dehydrated and dull skin: Rejuran stimulates fibroblasts to increase intrinsic hyaluronic acid synthesis in the dermis. This differs from injecting HA directly \u2014 the skin learns to hydrate itself more effectively, producing lasting radiance rather than temporary plumping.

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Enlarged pores and uneven texture: Improved dermal organisation and collagen density over a course of treatment smooth skin texture, reduce visible pore size, and even out surface tone progressively across 4 to 6 sessions.

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Acne scarring (atrophic and rolling): Rejuran S supports tissue repair and fibroblast regeneration in damaged skin, thickening and remodelling the dermis beneath the scar. Deep ice-pick or boxcar scars achieve optimal results when combined with Potenza RF microneedling.

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Under-eye skin quality: Rejuran I improves periorbital skin quality, reducing crepey texture and addressing mild dark circles caused by thin skin rather than vascular pooling \u2014 a clinically distinct problem from tear trough volume loss.

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Post-inflammatory and UV-damaged skin: Rejuran’s anti-inflammatory properties reduce chronic low-grade dermal inflammation \u2014 a key driver of premature ageing, particularly relevant in Abu Dhabi’s high-UV environment.

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Rejuran vs. Other Skin Treatments

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Rejuran vs. Profhilo: Profhilo injects high-concentration hyaluronic acid to hydrate and bioremodel the skin. Rejuran injects PDRN to stimulate cellular repair and collagen production. Both improve skin quality but through different mechanisms. Dr. Al Zaabi frequently combines them in a staged plan \u2014 Rejuran for regeneration, Profhilo for bioremodelling and hydration \u2014 for patients with multiple concerns.

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Rejuran vs. Skin Boosters: Skin boosters such as Juvederm Volite or Restylane Skinboosters deliver HA directly for immediate hydration. Rejuran does not add HA \u2014 it stimulates the skin to produce its own. The mechanism is regenerative rather than supplementative, and the timeline is different: Rejuran results accumulate over weeks; skin boosters are immediate.

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Rejuran vs. Dermal Filler: Dermal fillers add volume and structure. Rejuran does not. It is a skin quality treatment, not a volumiser. Patients with both skin quality concerns and volume loss benefit from both \u2014 Dr. Al Zaabi assesses which is the priority at consultation.

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Rejuran vs. Microneedling: RF microneedling (Potenza) creates controlled skin injury to stimulate collagen. Rejuran stimulates collagen biochemically without injury. Both produce collagen but via different pathways. For acne scarring, combining Rejuran S and Potenza RF microneedling produces superior results to either alone.

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How Many Sessions Do You Need?

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A standard Rejuran course consists of 4 to 6 sessions spaced 2 to 4 weeks apart. The response is cumulative. Improved hydration is often noticeable after the first or second session, but the full structural improvement in collagen density and skin quality becomes apparent 8 to 12 weeks after the final session, as the fibroblast response fully matures.

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Maintenance is recommended every 4 to 6 months after the initial course. Patients in Abu Dhabi’s high-UV environment benefit from two maintenance sessions per year to sustain the fibroblast activity and protect the dermal investment.

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Younger patients in their 30s using Rejuran preventatively see strong early results. Patients in their 40s and 50s with significant volume loss or deep lines benefit from combining Rejuran with a biostimulator such as Profhilo or Sculptra as part of a staged treatment plan \u2014 which Dr. Al Zaabi can map out at your initial consultation.

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What to Expect at Your Session

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Topical anaesthetic cream is applied to the treatment area and left for 20 to 30 minutes. Rejuran is then injected in a papule pattern at mid-dermal depth using a fine-gauge needle \u2014 multiple small raised dots across the treatment area. These papules are the PDRN depot points from which the treatment diffuses into the surrounding dermis. They flatten within 24 to 48 hours. Most patients describe mild stinging at injection points; the periorbital area is more sensitive than the cheeks or forehead.

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Immediately after treatment, the skin appears slightly red with the raised papule dots visible. This resolves within 24 hours. There is no peeling, no significant swelling, and no social downtime for most patients. Makeup can be applied the following day. Sun exposure should be avoided for 48 hours and broad-spectrum SPF used consistently \u2014 especially in Abu Dhabi’s climate \u2014 to protect the regenerating dermis.

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Is Rejuran Right for You?

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Rejuran Healer is suitable for most adults who want to improve skin quality \u2014 texture, hydration, fine lines, and density \u2014 rather than add volume. It is appropriate from the late 20s onwards as a preventative treatment, and highly effective in the 30s through 50s for progressive skin quality decline.

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It is not appropriate for patients with confirmed fish or seafood allergies, as the active ingredient is derived from salmon milt. Dr. Al Zaabi reviews allergy history at consultation. Patients who are pregnant or breastfeeding, or who have active skin infections in the treatment area, should defer treatment.

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The best outcomes come from a full course consistently completed, combined with daily SPF use and a physician-directed skincare routine. Dr. Al Zaabi assesses your skin holistically at consultation and recommends whether Rejuran alone or in combination with other treatments best addresses your goals.